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Abnormal Cobalamin-dependent Transmethylation in AIDS-associated Myelopathy Neurol 58:730-735, Di Rocco,A.,et al, 2002 See this aricle in Pubmed Article Abstract White matter vacuolization of the spinal cord is common in patients with AIDS and may lead to clinical manifestations of myelopathy. The pathogenesis of AIDS-associated myelopathy (AM) is unknown and may be related to metabolic abnormalitie s rather than to direct HIV infection. The striking pathologic similarity between AM and the vacuolar myelopathy associated with vitamin B12 deficiency suggests that abnormal metabolism of the B12 -dependent transmethylation pathway may be important in t he pathogenesis of AM. AM is associated with an abnormality of the vitamin B12-dependent transmethylation pathway.

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(click to filter results - removes previous filter) acquired immunodeficiency syndrome B 12 deficiency B 12 metabolism,defective human immunodeficiency virus type 1 myelopathy myelopathy,vacuolar

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